Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet
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Last updated 05 julho 2024
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JCDD, Free Full-Text
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News at XI: moving beyond factor Xa inhibitors - ScienceDirect
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Full article: Antiplatelet therapy after noncardioembolic ischemic
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(BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.glpbio.com/media/struct/GC6/GC65912.png)
Asundexian
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.jacc.org/cms/asset/24eb4ecf-f037-449e-a726-2ebc8e27cb77/ga1.jpg)
Antithrombotic Therapy for Primary and Secondary Prevention of
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://ars.els-cdn.com/content/image/1-s2.0-S1052305722004360-gr1.jpg)
Rationale and design of the AXIOMATIC-SSP phase II trial
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://assets.radcliffecardiology.com/s3fs-public/video/2022-08/DELV_10061_IND_ESC_Shoamanesh_1920x1080%20%282%29.png?VersionId=1xZCLNAZkcz1kVksf_F.kxe3ypus3FQ6)
ESC 22: Dosing of Asundexian in Pts With Non-Cardioembolic
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.ahajournals.org/cms/asset/b78e846b-6726-4f45-aaf4-f2d78d41dde6/strokeaha.121.036695.fig03.jpg)
Practical “1-2-3-4-Day” Rule for Starting Direct Oral
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://www.researchgate.net/publication/371383313/figure/fig2/AS:11431281166294430@1686229924828/Factor-XI-and-XII-structure-and-main-inhibitors-that-have-reached-phases-2-and-3-of_Q320.jpg)
PDF) The new era of anticoagulation: factor XI and XII inhibitors
![Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial - The Lancet](https://mms.businesswire.com/media/20220828005030/en/1555028/4/Bayer_Logo.jpg)
Bayer Initiates Phase III Study Program for Investigational Oral
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