PDF] Hepatoprotective Effect of Crotalaria longipes Wight & Arn , Ethanol Extract in CCl 4 Induced Hepatotoxicity in Wistar Rats

Ethanol extract of C.longipes have significant effect on the CCl4 induced hepatotoxic animal models and antioxidant activity, ethanol extract of Crotalaria longipes exhibited a significant effect showing increasing levels of SOD, CAT, GPx, GSH, and GRD by reducing malondialdehyde levels. ABSTACT The aim of the present study is to investigate the hepatoprotective activity of ethanol extract of aerial part of Crotalaria longipes in CCl4 induced hepatoprotective rats. Administration of hepatotoxins (CCl4) showed significant elevation of serum GOT, GPT, ALP, total bilirubin, conjugated, unconjugated and lipid peroxidation. Treatment with Crotalaria longipes (100, 200 and 400 mg/kg) significantly reduced the above mentioned parameters. Regarding antioxidant activity, ethanol extract of Crotalaria longipes exhibited a significant effect showing increasing levels of SOD, CAT, GPx, GSH, and GRD by reducing malondialdehyde (MDA) levels. The ethanol extract of C.longipes have significant effect on the CCl4 induced hepatotoxic animal models.

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Hepatoprotective Effect of Crotalaria longipes Wight & Arn, Ethanol Extract in CCl 4 Induced Hepatotoxicity in Wistar Rats